In 2014, the MAL071 study showed in controlled human malaria infection (CHMI) that the delayed fractional dose regimen of RTS,S/AS01 achieved our target efficacy level of >80%.
This project (MAL092) is a follow-on Phase 2a CHMI study designed to bridge the pediatric formulation of RTS,S/AS01E to adults and to test alternative schedules that may be more optimal for elimination campaigns. This study will take place at the Walter Reed Army Institute of Research (WRAIR) and is the largest CHMI ever conducted with a target of 150 participants.
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