Malaria transmission-blocking vaccines (TBVs) are potentially helpful tools for malaria eradication. The standard membrane-feeding assay (SMFA) is considered one of the “gold standard” assays for TBV development. However, lack of consensus in reporting results from SMFA has made it very challenging to compare results from different studies. Two main readouts, percent inhibition in mean oocyst count per mosquito (TRA) and percent inhibition in prevalence of infected mosquitoes (TBA), have been used widely.
29 Jul 2016