Vaccine Science Portfolio Advisory Council (VSPAC)

MVI makes routine use of external experts to move its research and development (R&D) strategy forward. As part of a carefully developed portfolio review process, MVI has established a Vaccine Science Portfolio Advisory Council (VSPAC), which is comprised of eminent malaria scientists and vaccinologists who meet at least once a year to provide strategic input and advice on MVI’s portfolio and overall R&D program.

Members

 

Norman Baylor, PhD

Dr. Norman W. Baylor is currently the President and CEO of Biologics Consulting Group, Inc. He was formerly the Director of the Office of Vaccines Research and Review (OVRR) in the US Food and Drug Administration’s (FDA) Center for Biologics Evaluation and Research. Prior to his position as Director, Dr. Baylor served as Deputy Director of OVRR and Associate Director for Regulatory Policy. He has evaluated and facilitated the development and licensure of numerous new vaccines, such as acellular pertussis, varicella, pneumococcal conjugate, human papillomavirus (HPV), influenza, Zoster, and all of the new-generation combination vaccines during his 20 year career at the FDA.

Dr. Baylor received his BS degree in medical microbiology from the University of Wisconsin, Madison, and his MS and PhD degrees in microbial genetics and molecular microbiology, respectively, from the University of Kentucky. Dr. Baylor spent three years as a postdoctoral Fellow at the University of Virginia School of Medicine in the Department of Microbiology and Immunology, and three years with Program Resources Incorporated as a Senior Research Scientist at the US National Cancer Institute-Frederick Cancer Research Facility. Dr. Baylor served as the FDA’s liaison to the US Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, the US Department of Health and Human Services National Vaccine Advisory Committee, and the Advisory Commission on Childhood Vaccines. Dr. Baylor continues to serve as an expert advisor to the World Health Organization on several global vaccine initiatives, including assessing national regulatory authorities worldwide.

 

John Boslego, MD

Dr. Boslego directs PATH’s vaccine development program, which seeks to identify and facilitate the development of safe, effective, affordable vaccines against select major disease threats in the developing world. Dr. Boslego’s career spans 30 years of service to private industry and the US government. Before joining PATH, he served as Executive Director of Biologics, Clinical Research, at Merck & Co., Inc. His portfolio at Merck included clinical development of a Haemophilus influenzae type b conjugate vaccine, a recombinant hepatitis B vaccine, an influenza DNA vaccine, a pneumococcal polysaccharide vaccine, a pneumococcal conjugate vaccine, various pediatric combination vaccines, a rotavirus vaccine, and a human papillomavirus vaccine.

For nearly two decades, Dr. Boslego worked for the Walter Reed Army Institute of Research in vaccine research—both in the laboratory and in clinical trials. He also directed the Armed Forces Research Institute of Medical Sciences in Thailand for three years.

Dr. Boslego received his medical education at George Washington University after graduating from the United States Military Academy.

 

Brendan Crabb, PhD (Chair)

Professor Brendan Crabb is Director and CEO of the Burnet Institute in Melbourne. Prof. Crabb's expertise is in the study of infectious diseases, particularly those affecting the developing world. The primary driver for his own laboratory's research is the development of a malaria vaccine and the identification of new targets for therapeutic intervention.

In addition, Prof. Crabb is the President of the Association of Australian Medical Research Institutes (AAMRI), the peak body representing 8,000 staff and students of Australia's 40 independent medical research organizations.

He is also Chairman of Alfred Medical Research and Education Precinct (AMREP) Council, Chairman of the PATH Malaria Vaccine Initiative's Vaccine Science Portfolio Advisory Council in the US, and Chair of the 2013 Gordon Conference on Malaria in Italy.

Prof. Crabb holds professorial appointments at The University of Melbourne and Monash Universities. Until his appointment as Director of the Burnet Institute, he was a Senior Principal Research Fellow of the National Health & Medical Research Council of Australia and an International Research Fellow of the US-based Howard Hughes Medical Institute.

He serves on the Scientific Advisory Boards of the Sanger Institute's Malaria Program and the Monash Institute of Pharmaceutical Science. Prof. Crabb was Editor-in-Chief of the International Journal for Parasitology from 2006 to 2009 and remains on its editorial board along with that of Nature Communications and F1000 Reports.

With a strong interest in education, the former lecturer in the Department of Microbiology and Immunology at The University of Melbourne is currently involved in educational and curriculum development activities for high school students and teachers through the Gene Technology Access Centre.

 

Tom Monath, MD

Dr. Monath is a Partner, Pandemic and Biodefense Fund, at Kleiner Perkins Caufield & Byers. He is also Chief Technical Officer of PaxVax Inc., Chief Medical Officer of Hookipa BioTech AG, a Director of Rapid Micro Biosystems Inc., and Adjunct Professor at the Harvard School of Public Health. Between 1992 and 2006, Dr. Monath was Chief Scientific Officer and Executive Director at Acambis (a publicly traded biopharmaceutical company), where he directed research and development on dengue, West Nile, Japanese encephalitis (using yellow fever as a live vector), yellow fever, and Clostridium difficile vaccines, as well as smallpox vaccine for defense against bioterrorism. Dr. Monath received his undergraduate degree from Harvard College and MD from Harvard Medical School and trained in internal medicine at the Peter Bent Brigham Hospital, Boston. Col. Monath retired from the US Army in 1992 after 24 years in the uniformed services (Army and US Public Health Service). Between 1973 and 1988, he was Director of the Division of Vector-Borne Viral Diseases at the US Centers for Disease Control and Prevention, Fort Collins, Colorado. From 1989 to 1992, he was Chief of the Virology Division at the US Army Medical Research Institute of Infectious Diseases.

Dr. Monath is on the editorial board of five scientific journals. He has received the Nathanial A. Young Award (1984), the Richard M. Taylor Award (1996), and the Walter Reed Medal (2002) from the American Society of Tropical Medicine and Hygiene and was President of that Society (2004–2005). He has served on numerous government and international committees on infectious diseases and biosecurity, World Health Organization expert committees, and the US National Vaccines Advisory Committee. Dr. Monath has published 385 papers and edited six books on the epidemiology, immunology, and pathogenesis of viruses and on vaccine development.

 

Rino Rappuoli, PhD

Dr. Rino Rappuoli is Global Head of Vaccines Research at Novartis Vaccines and Diagnostics and is based in Siena, Italy. He earned his PhD in biological sciences at the University of Siena and has served as a visiting scientist at Rockefeller University in New York and Harvard Medical School in Boston. Prior to the present position, he was Head of Research and Development at Sclavo and then Head of Vaccine Research and Chief Scientific Officer of Chiron Corporation.

Several molecules on which Dr. Rappuoli worked became, or are near to becoming, licensed vaccines. These include: CRM197, used in H. influenzae, N. meningitides, and pneumococcus vaccines; an acellular vaccine against pertussis containing a genetically detoxified pertussis toxin; the first conjugate vaccine against meningococcus C and later against meningococcus ACYW; MF59, used in a vaccine against pandemic influenza; and a genome-derived vaccine against meningococcus B currently under review by European and Canadian regulatory agencies.

He is an elected member of the US National Academy of Sciences and the European Molecular Biology Organization. Awards conferred include the Paul Ehrlich and Ludwig Darmstaedter Prize (1991), the Gold Medal by the Italian President (2005), the Albert B. Sabin Gold Medal (2009), the Lifetime Achievement Award from the Institute of Human Virology in Maryland (2010), and the Excellence Award from the European Society of Clinical Microbiology and Infectious Diseases (2011).

 

Professor David Salisbury, CB, FRCP, FRCPCH, FFPH

Professor David Salisbury is Director of Immunisation at the Department of Health, London, where he is responsible for the national immunization program.

Professor Salisbury graduated from London University in 1969. He trained as a pediatrician at Oxford and at the Hospital for Sick Children, London. He is a Fellow of the Royal College of Physicians, the Royal College of Paediatrics and Child Health, and the Faculty of Public Health. He has an honorary chair in the Department of Infectious Disease Epidemiology at Imperial College, London. Professor Salisbury was made a Companion of the Order of the Bath in Her Majesty the Queen’s 2001 Birthday Honours.

In addition to his UK responsibilities, Professor Salisbury works extensively with the World Health Organization (WHO) on the Global Programme for Vaccines. He was the Chair of the WHO Strategic Advisory Group of Experts on Vaccines from 2005 to 2010, is Chair of the European Region Certification Commission for Poliomyelitis Eradication, and is a member of the Eastern Mediterranean Polio Elimination Certification Commission and the South East Asian Polio Elimination Certification Commission. During 2009, Professor Salisbury chaired the WHO H1N1 vaccine working group. He is Co-chair of the Influenza Pandemic Preparedness Group for the Global Health Security Action Group of G7 countries. He is a liaison member of the US Advisory Committee on Immunization Practices and the US National Vaccine Advisory Committee. He also chairs the European Vaccine Advisory Group for the European Centre for Disease Control and is Co-chair of the research and development work stream for the Bill & Melinda Gates Foundation Decade of Vaccines initiative. He is a member of the Malaria Advisory Panel for the Gates Foundation and a Science Advisory Council member for the PATH Malaria Vaccine Initiative.

Professor Salisbury has written approximately 90 publications on immunization and pediatric topics.


Rafick-Pierre Sékaly, PhD

Dr. Rafick-Pierre Sékaly has been for the past two years the Co-Director and Chief Scientific Officer of VGTI Florida (the Vaccine & Gene Therapy Institute), which focuses on the development of better immune therapies and vaccines to chronic viral diseases and cancer. Dr. Sékaly obtained his PhD in biochemistry at the Université of Lausanne in 1984. He has been involved in the areas of AIDS and AIDS pathogenesis for the past 15 years. Dr. Sékaly’s group has been at the forefront of novel assay development which has allowed the characterization of the qualitative and quantitative features of the immune response at the single-cell level. He is now fully focused on applying systems biology to unravelling defects in different cells (innate and adaptive) of the immune response.

In addition to his scientific work and leadership at VGTI Florida, Dr. Sékaly is the Founder and Scientific Director of the National Laboratory of Immune Monitoring. In 2009, he was one of four winners of the Avant-Garde Award for HIV/AIDS research from the National Institute on Drug Abuse, for his work on the HIV reservoir. This award carries a grant of $500,000 per year for five years. Dr. Sékaly has also been awarded, with his colleagues at the University of California, San Francisco, a $25 million award for work aimed at identifying novel approaches to eradicate HIV.

 

Fidel Zavala, MD

Dr. Fidel Zavala is a Professor in the Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University. He initiated his research career at New York University School of Medicine in 1980. After a postdoctoral training in 1984, he joined the faculty as an Assistant Professor, and in 1999, he became Professor. In 2003, he joined Johns Hopkins University as Professor and member of the Malaria Research Institute. He has served as a member of the editorial board of Infection and Immunity, Experimental Parasitology, and Journal of Immunological Methods; as Editor of Parasitology International; and recently, as Associate Editor of The Journal of Immunology. He served as a member of the Advisory Board of the European Virtual Institute of Malaria Research, and since 2010, he is a permanent member of the US National Institutes of Health Pathogenic Eukaryotes Study Section.

The main focus of Dr. Zavala’s research is immunology of malaria parasite infections and vaccine immunology. He has published more than 130 scientific articles, on epitope characterization of antibody responses, development of subunit vaccines, and immunobiology of CD8+ T cell responses against malaria parasites.

 

Kathryn C. Zoon, PhD

Dr. Kathryn C. Zoon is the Director of the Division of Intramural Research (DIR) of the National Institute of Allergy and Infectious Diseases, US National Institutes of Health. The DIR conducts basic and clinical research related to infectious diseases, immunology, and allergy, with the ultimate goal of contributing to the development of new and improved therapies, diagnostics, and vaccines to improve human health. She also serves as the DIR’s Chief of the Cytokine Biology Section, which conducts research on the structure and function of human interferon alphas.

Dr. Zoon has more than 35 years of experience in the area of biomedical research and product development, of which almost a decade was spent as the Director of the Center for Biologics Evaluation and Research at the US Food and Drug Administration, an organization responsible for the licensing of hundreds of biological products. She is a member of the Institute of Medicine, Associate Editor of the Journal of Interferon Research, and the Federal Liaison to the Board of the International Association of Biologicals. In addition, she serves on the World Health Organization Expert Committee on Biological Standardization, the US Department of Defense Malaria Vaccine Program Scientific Advisory Board, and the US Agency for International Development Vaccine Development Scientific Consultants Group. She earned her PhD in biochemistry from Johns Hopkins University.


Observer

Vasee Moorthy, MD, PhD

Dr. Vasee Moorthy serves as the malaria vaccine focal point for the World Health Organization (WHO) in Geneva. He acts as Secretariat for two WHO malaria vaccine advisory committees—Malaria Vaccine Advisory Committee and Joint Technical Expert Group—which provide recommendations to WHO about malaria vaccine research and development and clinical evaluation. He facilitates the global Malaria Vaccine Funders Group and works to find synergies among funders to accelerate development of malaria vaccines for developing countries. His role includes coordination of development of global norms and standards within malaria vaccine development. He has previously served as Senior Program Officer in clinical vaccinology at the PATH Malaria Vaccine Initiative.

Dr. Moorthy has 15 years of experience covering clinical infectious diseases and tropical medicine, five years based in sub-Saharan Africa conducting malaria vaccine field trials and clinical malaria research. He serves on various data and safety monitoring boards and scientific advisory committees, is an editorial board member of PLoS ONE, reviews articles from academic journals, including The Lancet and The Lancet Infectious Diseases. He holds a BA (first class) in natural sciences from the University of Cambridge, a clinical medicine degree from the University of Oxford, and a PhD in malaria immunology from the Institute of Molecular Medicine, Oxford.