The biological processes associated with protection from malaria following vaccine delivery are largely unknown. Transcriptome analysis provides an opportunity to indirectly measure the expression of proteins linked to a wide array of biological processes and make quantitative comparisons between pre- and post-vaccination production levels. This analysis allows for broad, un-biased screening and potential identification of novel processes linked to vaccine responsiveness or efficacy.  Single processes or networks of processes that are identified in this manner may also be valuable surrogate markers of immunity or protection from malaria, helping to guide future vaccine development.