The PATH Malaria Vaccine Initiative (MVI) and the US Agency for International Development (USAID) are working together to enhance the ability of enzyme-linked immunosorbent assays (ELISAs) and other laboratory tools to evaluate the potential of new vaccine candidates. As part of this initiative, MVI and USAID are supporting the International Reference Center for Malaria Serology Laboratory (MSL) within the US Military Malaria Vaccine Program (USMMVP). The MSL is the only international reference center that performs ELISAs using vaccine-grade malaria plate antigens.