28 Jul 2017
Author(s): 
Bompard A, Da DF, Yerbanga RS, Biswas S, Kapulu M, et al.

This article, published in Scientific Reports, describes the assessment of antibodies against leading transmission-blocking vaccine candidates, Pfs25 and Pfs230, using naturally-occurring parasites and local mosquito strains in direct membrane feeding assay (DMFA) experiments.  According to this article's findings, data shows the transmission-blocking activity of both candidates depends on the level of parasite exposure and antibody titers. These observations will influence how and where a transmission-blocking vaccine can be tested in the field, and where it could have the most impact in accelerating malaria parasite elimination.