16 Nov 2017
Scally SW, McLeod B, Bosch A, Miura K, Liang Q, et al.

In this article, published in Nature Communications, PATH/MVI and partners report the molecular definition of two distinct sites associated with antibody-mediated inhibition of mosquito infection on a leading transmission-blocking vaccine antigen, Pfs25. The molecular characterization of inhibitory antibodies informs the natural disposition of Pfs25 on the surface of parasites as they infect mosquitoes, and provides the structural blueprints to design next-generation immunogens.