This article, published in PLoS Pathogens, reports on the influence of the number of sporozoites in the salivary glands of mosquitoes relative to their infectivity. According to the authors' findings, although it had previously been assumed mosquitoes were equally infectious regardless of the actual number of sporozoites carried, those harboring >1000 sporozoites had a per-bite transmission probability of 9.2% , while those with fewer parasites did not measurably contribute to transmission—arguing for additional considerations when planning and interpreting data from experimental and natural malaria infections.