This article, published in Frontiers in Immunology, describes a comprehensive evaluation of cellular responses to the RTS,S/AS01E malaria vaccine containing  circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg). The study found that vaccination with RTS,S induces CSP- and HBsAg-specific T cells to produce an assorted range of interleukin 2, tumor necrosis factor alpha, CD40 ligand, interferon gamma, and interleukin 17 proteins. These findings suggest that such responses in memory T cells may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future studies.